The “Deal or No Deal Island” host will dig deep into his lengthy health ordeal in his upcoming memoir, “Bloodlines.”

Joe Manganiello reveals private 7-year health battle, life-saving organ removal

The "Deal or No Deal Island" host will dig deep into his lengthy health ordeal in his upcoming memoir, "Bloodlines."

By Emlyn Travis

Emlyn Travis

Emlyn Travis is a news writer at **. She has been working at EW since 2022. Her work has previously appeared on MTV News, Teen Vogue, and NME.

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June 23, 2026 1:33 p.m. ET

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Joe Manganiello in Las Vegas last year. Credit:

Ethan Miller/Getty

- Joe Manganiello is detailing a 7-year-long health battle he experienced in his upcoming memoir, *Bloodlines*.

- The* True Blood* actor said the scare began as a "cascade of autoimmune-related illnesses" that led to multiple near-death encounters and a "life-saving organ amputation."

- Bloodlines will be released on Oct. 16.

Joe Manganiello is opening up about a serious health scare in his upcoming memoir, *Bloodlines*.* *

The book, which hits shelves on Oct. 16, follows the 49-year-old *True Blood* actor as he details “a previously undisclosed health ordeal — marked by multiple near-death experiences and medical crises — that led him beyond medicine and into a remarkable, globe-spanning quest that revealed answers about his ancestry, inherited trauma, and the deeper histories we carry,” per a press release.

In it, Manganiello writes that his health suddenly deteriorated “without warning” one day as “a cascade of autoimmune-related illnesses attacked his skin, thyroid, eyes, lungs, and digestive system,” the synopsis reads.

Manganiello at the 2025 SXSW Conference & Festivals in Austin.

Amy E. Price/SXSW Conference & Festivals via Getty

The mysterious ailments led to a seven-year-long health battle in which Manganiello was “plagued by chronic pain” and underwent a “life-saving organ amputation, existential crisis, and a prolonged fight for survival that left doctors with few answers and no clear explanation,” the synopsis continues.

The* Deal or No Deal Island *host described the period as “the most brutally difficult time in my life” in a statement to PEOPLE, adding, “One I wouldn’t wish on my worst enemy, but also my greatest adventure.”

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He continued, "I hope that what I went through on this journey can give readers hope that answers and healing may lie for them on the other side of whatever they are fighting through. The process of writing this book gave me the gift of perspective that helped me to see that my suffering was a cocoon from which I would emerge forever changed.”

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In addition to his health battle, *Bloodlines* will also see Manganiello reflect upon “inheritance, masculinity, faith, ambition, and the identities we build to endure,” the synopsis shares.

*Bloodlines* is set to hit bookshelves on Oct. 16.

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